ResearchMy research is focused on the application of theoretical computational tools developed in soft condensed matter physics to investigate the phase behaviour and transitions of complex systems of biomolecules. From a purely statistical mechanical point of view an ensemble of many peptides and proteins represents a new and important system which should lead to bridge our understanding of colloidal systems, polymers, and proteins. Examples of transitions that I investigated include colloidal crystallization and the aggregation of proteins into amyloid fibrils. My long term goal is to understand more generally the nucleation and regulation of normal and aberrant self-assembly in biological systems, and how we can functionalise them as nanomaterials.
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Selected publicationsUniversality in the morphology and mechanics of coarsening amyloid fibril networks
L.G. Rizzi, D.A. Head and S. Auer, Phys. Rev. Lett., 114 078102 (2015)
Nucleation of polymorphic amyloid fibrils
S. Auer, Biophys. J., 108 1176 (2015)
Confounding the paradigm: Pecularities of amyloid fibril nucleation
D. Kashchiev, R. Cabriolu and S. Auer, J. Am. Chem. Soc., 135 1531 (2013)
Two-step nucleation of amyloid fibrils: Omnipresent or not?
S. Auer, P. Ricchiuto and D. Kashchiev, J. Mol. Biol., 422 723 (2012)
Phase phenomena in supported lipid films under varying electric potential
A. Brukhno, A. Akinshina, C. Zachary, A. Nelson, and S. Auer, Soft Matter, 7 1006 (2011)
Phase diagram of α-helical and β-sheet forming peptides
S. Auer, and D. Kashchiev, Phys. Rev. Lett., 104 168105 (2010)